Is it Possible to Control Blood Sugar Levels Without Medicine?

Scientists have advanced knowledge about the proteins that help control blood sugar, or glucose, during and after exercise, and this knowledge could lead to new drug therapies or exercises more effective for the prevention of Type 2 diabetes and other health problems associated with high levels of blood sugar.

Insulin resistance occurs when the body is not produced by properly stimulating the transport of glucose, a type of sugar inside the cells as an energy source. Too much glucose in the bloodstream can cause a variety of medical problems including Type 2 diabetes, said Gregory Cartee, a professor in the School of Kinesiology and principal investigator of the study. Katsuhiko Funai is the co-author, graduate student and researcher in the School of Kinesiology.

Insulin and muscle contractions are the most important stimuli that increase glucose transport into the interior of muscle cells. The cells can then use glucose for energy, said Cartee. But scientists do not know exactly how this works.

The group reacted Cartee watched two different proteins that were considered important in stimulating the transport of glucose by two different enzymes, linked also with the transport of glucose. The goal of this study was to understand the contribution of the two proteins, called AS160 and TBC1D1 in skeletal muscle stimulated by insulin.

“Trying to rule out or determine what proteins are important in the exercise,” said Cartee.

The results indicate that the protein TBC1D1 was the most important for the transport of glucose stimulated by exercise and suggested that the second protein, AS160, may be less important for this effect of exercise. Give attention to the protein works best, in this case the TBC1D1, scientists can develop methods for making proteins that work best for people with insulin resistance, Cartee said.

Insulin resistance is a major health problem affecting millions of people, he said.

“Almost all people with diabetes have Type 2 muscle resistance to insulin,” said Cartee. “This does not cause diabetes by itself, but it is an essential component that contributes to type 2 diabetes. This affects millions of people. Even people who are not diabetic insulin resistance is linked to numerous health problems. “

In the longer term people who have insulin resistance or whose muscles do not respond normally to insulin are more likely to develop Type 2 diabetes, said Cartee.

“Apparently the muscles have the machinery to respond to exercise even if they do not respond normally to insulin. If we knew how the exercise could develop more effective protocols for exercise, “he said. “In other cases of people who can not exercise, we could design a drug therapy or something else to control insulin.

Shopping for Gifts on a Budget

Holiday shopping is seldom easy. Whether you're just hopping around department stores or just surfing the net, the limitless choices made available by advertisers can actually be more of a detriment for someone who is in a real hurry. This can be quite problematic if you're on a budget and have such a long shopping list. Time constraints do not really provide you the benefit of thoroughly comparing every item in each store in an effort to find yourself the best bargain. One who has been shopping for hours can quite easily succumb to the pressure and end up buying gifts beyond a planned budget.

If you're in this very familiar predicament, all is not lost. When shopping for holiday gifts it sometimes makes more sense to look for items that are simple yet meaningful. While a sophisticated electronic gadget could certainly get a friend excited, simple inexpensive gifts like personalized mugs or engraved pens may just elicit the same amount of appreciation.

Nothing is perhaps more appropriate than a gift that actually captures the holiday spirit. As holidays bring sentimental moments, you'd want to give something you would be remembered for. Embroidered pillows and blankets would be good choices. Collectibles like cd's and personalized caps should also do the trick. Listed below are some gift items worth considering:

• shirt of a home team

• cross stitching kit

• bottle of a local wine

• personalized notepad

• stationary

• photo album

• memo holders

• tool kits

• Carpentry kits

• versatile pocket knife

While you'll certainly be shaved with praises by giving a fancy cellphone or notebook, it sometimes makes more sense to go for something more practical yet thoughtful. You do not really have to dent your budget to please a friend. People tend to get appreciated more for the amount of effort that they've performed in looking for that meaningful gift that touches the heart. Whether it's Christmas, Thanksgiving, or a major school reunion, there's really no reason to panic. All it takes is just a little imagination and a touch of creativity.

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Benefits of Internet Marketing Services With The New Approach to Marketing

The internet has radically changed the face of shopping as we know it. Now the virtual marketplace is becoming every bit as important as the high street. With this new form of shopping coming a new form of marketing which is not necessarily the same as traditional marketing and therefore demands a new approach and also a degree of stepping away from the mindset of traditional marketing such as television and magazine advertising. The positive side of this however, is that the potential of internet marketing is unlimited. It not only moves your business out of the locality in which you are based, but also outside of your national borders. It is creating a global marketplace with access to billions of customers. The internet population of China alone is bigger than the population of the US. Therefore, it is imperative that you make the correct decisions when it comes to online marketing and the proposal of internet marketing services. If you do so there are a number of important benefits to be had.

Cost-Effective

Internet marketing services can be expensive; however, when you take into account the impact they can have the cost-benefit ratio far thats that of traditional marketing techniques. Due to the nature of the internet by choosing the right internet marketing services it is possible to reach a massive target population. A good internet marketing company, although costly, will be able to work out the exact demographic that your business targets and assist you with reaching them.

Specialists

Whilst you are paying for their services it is important to realize that they are specialists in their field and you are not only paying for their services but also their knowledge. It is important that you never assume to know what an online customer wants or how to reach them as you may simply not be correct and then your market will fail to be reached. There are millions of websites out there that have missed the mark and receive few or no visitors.

Strategic

A good internet marketing services provider will also be able to assist you in developing a very strategic marketing plan taking into account the many different elements of internet marketing such as SEO, advertising, and social media marketing. It would be extremely difficult for an internet marketing novice to be able to truly engage with any of these forms of marketing as they have particular nuances.

Increase Sales

Ultimately one of the main benefits of engaging an internet marketing services provider is the fact that they have the experience to help you increase your sales. This is the end game of the online marketplace – driving traffic to your website and converting that traffic to sales. Not only is it important to work out how to get customers to your website it is also important that once there your website is well-built enough to actually convert sales. A company with a good reputation for providing internet marketing services will be able to assist you with all angles of marketing to ensure you get the most for your money. Remember there are already people out there searching for your product; it is just a matter of making your company visible to them.

Some Things Your Car Insurance Company Won’t Tell You

1. How to determine the value of “total loss.”

Most companies will tell you that they use at least three methods or schemes to determine the actual a totaled vehicle’s value including value books, computer-generated quotes from dealers, and local market research. In this case, you will probably think that local area is your current neighborhood, but it is not specifically defined by the insurer. If, in any case, the company cannot find an auto replacement in your neighborhood, so they have to find it not from your “local area,” your totaled car’s value is certainly affected. For example, if you currently live in New York, replacing your totaled vehicle in suburbs will be cheaper than in the city. Insurance company will, of course, use quotes from suburbs area as the most-reasonably-priced estimates. The main purpose in totaling a vehicle is to allow the consumer (the insured person) to purchase the same car that is totaled in an accident within the local market. Since they use three different schemes to figure out real value of a totaled car, a consumer may end up with a cheaper car than the totaled one. It is impossible to be sure what value you will get when your company does not tell you how they determine it.

Fortunately, you can do some smart methods to help yourself and your company to do the value determination. First, you have to produce valid proof that your car was in good conditions when the accident occurred; car in good condition has better value than a wreck. Bring a copy of maintenance records including oil changes and inspection by an authorized mechanic. The records will tell your company that your auto was regularly maintained, meaning it was actually in great shape (in terms of appearance and performance) when the accident occurred. Moreover, you probably had special features installed such as multimedia system, anti-theft system, anti-lock brakes, rear view camera, or 5-harness seat belt. The car insurance company may charge you more because of some special upgrades, so make sure that your insurer includes that in the evaluation.

Another good thing is to find at least three dealers and get quotes on replacement from them; make sure all dealers in your local area or at least within short driving distance from your home. Present the quotes to your insurer and ask your insurer to provide a list of some car dealers who probably can provide a car for the price listed in the quotes. If you are not satisfied with the company’s value determination or you get less than you expect, you can choose to do mediation. So, meaning you present the case to third party (neutral) to get help to settle the dispute, or arbitration, or you can even request a formal inquiry to the court.

2. If you want to cancel your policy, do it officially

Most companies say that consumers can cancel their policies at any date, but you need to notify the insurer concerning the exact date you want to end the coverage. The statement is clear enough; in other words, it says consumers have to notify their companies when they want to cancel their policies. However, consumers often think that when they ignore the last bill before renewal, the company will automatically end the policy. Too bad, this is not how it is done. People can forget and deliberately miss a bill, and the company totally understands that. After this first missed bill, your insurer is going to send you one more bill for premium payment; if you don’t pay the bill, you will be cancelled for non-payment, and the record will hurt your credit score.

What you should do when you want to cancel auto insurance policy is to let the company know that you are canceling. Please make sure that you provide a specific date; it helps you avoid being totally uninsured for a certain period, time, term. The cancellation request will be sent to you, and all you have to do is to put your signature. It is recommended that you carefully check the document before signing it. Some companies may require you to provide valid proof that you indeed have another coverage before they can approve the cancellation. If you’ve financed your car, the dealer needs the updated policy information because valid proof of insurance is required in the purchase contracts.

Credit history still matters

The use of credit information to determine approval and premium rate is still common, despite the fact that some states already started to ban such practice. Some (if not most) companies use the credit history to generate risk score. They believe that it strongly linked or correlated to the likelihood of the consumer reporting a claim. More likelihood of filing a claim is exactly the same with high-risk driver that usually also pays more expensive premium fee compared to “safe-driver” or “the preferred class.” The preferred consumers are those with stable credit card history as it suggests financial stability, meaning they are not likely to miss a payment. People of this category are safer consumers to insure compared to people with shaky credit history. Auto insurance companies do not like consumer who pays sporadically or changes accounts quite frequently.

There are some credit card issuers who offer free credit score checking, but in most cases, you need to pay for the service. Unlike credit score, risk score for insurance-related matters will not be available for you, but both probably indicate the same thing which is financial stability. If you are currently in the market to purchase auto insurance, and it turns out that you have quite unusual activity on your credit history within only certain time frame, you can wait until one month to allow the credit activity to go back to its usual condition. If you cannot keep the credit score stable, prepare yourself to pay more expensive premium fee.

3. Budgeting by installments is not always efficient.

Installments can pay almost all items, and consumers think that it is indeed the best way to budget the expense. When it comes to auto insurance, you can ask the company to divide the annual premium into a monthly basis, quarterly, or on six month. Please put in mind that dividing the annual premium will cost you “fractional premium.” You can consider this additional service fee to arrange the installment. It can be as cheap as $10 per payment; the more you break it down, the most fractional premium to pay.

Most companies will probably offer you to pay in installments since it makes more money for them. When you apply for insurance, it is wise to ask whether there is any additional charge for installments option, and then you can compare the difference. If the fractional premium is not very expensive, then perhaps it is worth it. Another big difference between upfront payment and installments is that certain companies will immediately cancel your coverage if you miss one payment; even worse, they can do it without notification. It is best to pay up front if you can; the entire process will be easier, and you can indeed save few dollars.

Every vehicle model and type has certain premium rate

Of course, you all know that sport cars need more expensive insurance policies than a van, but insurance companies will not tell you the exact numbers. In general, it is true that attractive, sporty, luxurious car with turbocharged engine will go very quickly on the road, and it increases the risk of accidents, but this is not always true considering the discounts for safety features, security features, mileage (especially when you drive it less), etc. Auto insurance companies have a specific system to know the premium for all car models you can buy, based on the system rating by ISO (Insurance Service Office). Every type of car is rated from 3 to 27; higher number means a higher premium. Insurance Service Office says that it will not release the rating system for publication because its clients are insurance companies.

You will not get the rating system from your insurer; you may not even find it anywhere at all. The best thing you can do when you want to purchase a new auto is to ask the insurance how much insurance premium you need to pay for a new car that you want to purchase. If you keep a good relationship with an independent agent, he/she should be able at least to predict the price based on raw calculation.

4. Filing claim increases your premium.

People are always interested to see insurance companies reduce premium fee to attract potential customers. It is indeed one of the best things customers get from the competition in the market, but your insurer can increase the price right away after you file your first claim. The industry standard is to increase premium fee up to 40% of the base rate after first-at-fault accident. With the help of an online car insurance calculator you get a base rate of $500, your premium increases by $200. Some companies have different rules, but there is always a big chance your premium will go up after the first-at-fault claim. Some insurers offer “first-accident forgiveness,” meaning your first actual claim will not affect the premium at all, but the variable and requirement for eligibility can be different from company to company. You should ask your insurer if such discount is available and how to qualify for it.